The latest Centre for Cities index ranks Brighton ahead of London, Oxford and Cambridge for the highest proportion of creative SMEs relative to the size of its small and medium sized [SME] business base.
One in every eight SMEs is the city is operating in the creative, digital and IT [CDIT] sector.
Along the coast Hastings and Worthing were ranked sixth and tenth respectively.
Brighton has the third highest density of SMEs overall, with 370 per 100,000 of the population and the fourth highest number of start-ups per head of population, with 66.4 per 100,000.
The research shows UK cities which have high numbers of small firms in the creative, digital and IT sector are also the most successful places in terms of jobs growth, productivity and average wages.
Average productivity per worker ranked Brighton19th out of 64 cities but average earnings at £24,800 p.a. were ranked 43rd .
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Centre for Cities